What question did this study set out to answer?

Investigate how the cervical sympathetic nerve affects oxygen consumption and blood flow in the carotid body.

August 1, 1970The Journal of PhysiologyOpen Access

The role of the cervical sympathetic nerve in the regulation of oxygen consumption of the carotid body of the cat

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Population

26 cats anaesthetized with pentobarbitone sodium, paralysed with gallamine triethiodide and ventilated…

Comparison

Section or stimulation of the pre- or… vs Intact sympathetic nerves

Design

Preclinical

Authors

MPM. J. PurvesThe University of Sydney

Discussion

Member takes

Implication

Sympathetic vasoconstriction may limit carotid body perfusion and metabolism in animals; leaves open relevance to human chemoreflex regulation.

Key Points

Investigate how the cervical sympathetic nerve affects oxygen consumption and blood flow in the carotid body.
Measured carotid body blood flow and oxygen consumption in 26 anesthetized cats.
Examined effects of cervical sympathetic nerve section and stimulation on blood flow and oxygen measurements.
Analyzed responses under varying conditions of arterial gas tensions and mean arterial pressure.
Sectioning the cervical sympathetic nerve raised blood flow by 9.2 µL/min and increased oxygen consumption by 0.075 µL/min.
Sympathetic stimulation decreased blood flow and oxygen difference, particularly under low arterial pressure or high CO2.
After removing sympathetic nerves, alterations in blood pressure still resulted in stable oxygen consumption despite changes in blood flow.

Structured PICO

Population

26 cats anaesthetized with pentobarbitone sodium, paralysed with gallamine triethiodide and ventilated mechanically

Intervention

Section or stimulation of the pre- or post-ganglionic cervical sympathetic nerve

Comparator

Intact sympathetic nerves

Outcome

Carotid body blood flow, carotid arterial-carotid body venous oxygen difference, and carotid body oxygen consumptionsurrogate

The cervical sympathetic nerves exert a vasoconstrictor effect upon carotid body blood vessels and tend to diminish the rate of carotid body oxygen consumption.

Cite This Study

M. J. Purves (1970) studied this question.

synapsesocial.com/papers/6a196b4dac919e0a48890eb3 https://doi.org/10.1113/jphysiol.1970.sp009172

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Implication

Sympathetic vasoconstriction may limit carotid body perfusion and metabolism in animals; leaves open relevance to human chemoreflex regulation.

The role of the cervical sympathetic nerve in the regulation of oxygen consumption of the carotid body of the cat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The role of the cervical sympathetic nerve in the regulation of oxygen consumption of the carotid body of the cat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider