What question did this study set out to answer?

To determine whether the quantitative volume of contrast enhancement on immediate post-thrombectomy non-contrast CT predicts symptomatic intracranial hemorrhage and functional outcomes in acute large vessel occlusion stroke.

May 29, 2025Frontiers in NeurologyOpen Access

Quantitative contrast enhancement volume on immediate post-thrombectomy CT predicts symptomatic intracranial hemorrhage and functional outcomes in acute large vessel occlusion stroke

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Authors

ZHZiyang HuangAnhui University ZXZhiyu XiongJiangsu University GCGong ChenAcademy of Medical Sciences

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Implication

Retrospective study reveals that contrast enhancement volume predicts brain hemorrhage in stroke patients, suggesting a novel prognostic biomarker.

Key Points

To determine whether the quantitative volume of contrast enhancement on immediate post-thrombectomy non-contrast CT predicts symptomatic intracranial hemorrhage and functional outcomes in acute large vessel occlusion stroke.
Retrospectively screened 111 consecutive acute ischemic stroke patients with anterior circulation large vessel occlusion who exhibited contrast enhancement on non-contrast CT within 2 hours after endovascular thrombectomy.
Quantified contrast enhancement volume using 3D Slicer software and determined an optimal dichotomization threshold using restricted cubic splines.
Identified predictors of symptomatic intracranial hemorrhage and functional independence via multivariable logistic regression, evaluated with fivefold cross-validation, receiver operating characteristic, and calibration curves.
A contrast enhancement volume exceeding the 10.6 mL threshold independently predicted symptomatic intracranial hemorrhage (aOR 5.24, 95% CI: 1.45–18.99, p = 0.012).
Patients with contrast enhancement volume above 10.6 mL achieved significantly lower rates of functional independence compared to those below the threshold (10.9% vs. 51.8%; aOR 0.05, 95% CI: 0.01–0.28, p < 0.001).

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/6a196c69f2eb401dc7891136 https://doi.org/10.3389/fneur.2025.1579659

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Implication

Retrospective study reveals that contrast enhancement volume predicts brain hemorrhage in stroke patients, suggesting a novel prognostic biomarker.

Quantitative contrast enhancement volume on immediate post-thrombectomy CT predicts symptomatic intracranial hemorrhage and functional outcomes in acute large vessel occlusion stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Quantitative contrast enhancement volume on immediate post-thrombectomy CT predicts symptomatic intracranial hemorrhage and functional outcomes in acute large vessel occlusion stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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