What question did this study set out to answer?

Evaluate the clinical utility of antithrombin III concentrates in controlling acute deep venous thrombosis in patients with familial antithrombin III deficiency.

June 28, 2008Clinical & Laboratory Haematology

Treatment of venous thrombosis in antithrombin III deficient patients with concentrates of antithrombin III

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Authors

JWJ H WinterUniversity of South Wales AFA FenechMater Dei Hospital MMM. MackieUniversity of Aberdeen

Discussion

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Implication

Clinical report reveals antithrombin III concentrates limit thrombosis progression in antithrombin deficiency, suggesting therapy helps prevent pulmonary embolism.

Key Points

Evaluate the clinical utility of antithrombin III concentrates in controlling acute deep venous thrombosis in patients with familial antithrombin III deficiency.
Evaluated two patients (N=2) with familial antithrombin III deficiency presenting with deep venous thrombosis of the lower limb.
Administered combination therapy with warfarin, subcutaneous heparin, and antithrombin III concentrate infusions.
Tracked daily thrombus extension and therapeutic response using an indium-labelled platelet imaging technique.
Infusion of antithrombin III concentrates restricted the expansion of acute thrombi, supporting its utility in preventing secondary pulmonary embolism.
Combining modest doses of subcutaneous heparin with high-dose antithrombin III concentrate showed a low perceived risk of haemorrhage.
Indium-labelled platelet scintigraphy provided early qualitative detection of thrombus growth to evaluate ongoing treatment efficacy.

Cite This Study

Winter et al. (2008) studied this question.

synapsesocial.com/papers/6a196ea5ff42a97fac5825c9 https://doi.org/10.1111/j.1365-2257.1982.tb00336.x

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Implication

Clinical report reveals antithrombin III concentrates limit thrombosis progression in antithrombin deficiency, suggesting therapy helps prevent pulmonary embolism.

Treatment of venous thrombosis in antithrombin III deficient patients with concentrates of antithrombin III

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment of venous thrombosis in antithrombin III deficient patients with concentrates of antithrombin III

Discussion

Member takes

Implication

Key Points

Cite This Study

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