Why the study?
Does hormone replacement therapy improve arterial stiffness in healthy postmenopausal women?
Does hormone replacement therapy improve arterial stiffness in healthy postmenopausal women?
Hormone replacement therapy does not appear to reduce arterial stiffness in healthy postmenopausal women, suggesting other mechanisms for cardiovascular risk reduction.
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No arterial stiffness benefit seen with HRT; leaves open alternative mechanisms for CVD risk reduction in postmenopausal women.
BACKGROUND: Arterial stiffness has been shown to be positively related to cardiovascular disease risk. Little, however, is known about the influence of hormone replacement use on arterial stiffness in females. METHODS: Arterial pulse wave velocity (PWV) and carotid augmentation index (AI, applanation tonometry) were measured in 34 healthy postmenopausal women, including users (n = 18) and nonusers (n = 16) of hormone replacement. RESULTS: There were no significant group differences in any of the physical characteristics including resting blood pressure. None of the measures of arterial stiffness differed between user and nonusers of hormone replacement. CONCLUSIONS: The present cross-sectional study indicates that reduced arterial stiffness does not appear to be a likely mechanism contributing to the lower incidence of cardiovascular disease in postmenopausal women taking hormone replacement.
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Tanaka et al. (1998) studied this question.
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