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Forty-four per cent of 112 patients with anxiety neurosis reported episodes of depression during the course of their illness compared with only 7 per cent of surgical controls. Although the majority developed in response to environmental circumstances and were of brief duration, they commonly led to psychiatric treatment or hospitalization in this group of patients. Patients who developed this complication were shown to have a more chronic and severe underlying illness.
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Clancy et al. (1978) studied this question.
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