Population
Patients after surgery, myocardial infarction, and severe trauma
Design
Cohort
Follow-up
postoperative period (first postoperative day)
Authors
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May increase perioperative thrombotic risk; extends mechanistic insight into fibrinolytic shutdown but remains hypothesis-generating.
The postoperative fibrinolytic shutdown is primarily driven by a rapid, temporary increase in t-PA inhibitor levels.
Kluft et al. (1985) studied this question.
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