Population
Normal and obese db/db mice (model of human diabetic nephropathy), human diabetic kidneys, and cell culture
Comparison
Diabetes/obesity and thrombin treatment in cell… vs Normal mice, non-diabetic tissues, untreated cells
Design
Preclinical
Authors
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Should not yet change practice in diabetic nephropathy; leaves open SGK as a research target.
Sgk mRNA is selectively upregulated in diabetic kidneys and by thrombin, suggesting a potential role in the pathogenesis of diabetic nephropathy.
Kumar et al. (1999) studied this question.
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