What does this research mean for the field?

Untreated patients with primary aldosteronism exhibit significantly greater urinary albumin and beta2-microglobulin excretion compared to matched patients with essential hypertension. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1995Journal of Hypertension

Albuminuria in untreated patients with primary aldosteronism or essential hypertension

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Why the study?

Is primary aldosteronism associated with increased urinary albumin excretion compared to essential hypertension in untreated patients?

Structured PICO

Is primary aldosteronism associated with increased urinary albumin excretion compared to essential hypertension in untreated patients?

Population

69 never-treated patients, including 23 with documented primary aldosteronism (12 males, 11 females; 11 tumoral, 12 non-tumoral) and 46 with essential hypertension (23 low renin, 23 normal renin), matched for age, body mass index, mean arterial pressure, renal function, and known duration of hypertension.

Intervention

Primary aldosteronism (disease state)

Comparator

Essential hypertension with low renin (supine plasma renin activity <1 ng/ml per h) or normal renin (supine plasma renin activity between 1 and 4 ng/ml per h)

Outcome

Urinary albumin excretionsurrogate

Discussion

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Implication

Primary aldosteronism is associated with excessive urinary albumin excretion compared to essential hypertension, which may indicate target-organ damage or proximal tubular impairment.

Cite This Study

Halimi et al. (1995) studied this question.

synapsesocial.com/papers/6a197abfa0353395e9586799 https://doi.org/10.1097/00004872-199512010-00054

Topics

Hypertension management

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Implication

Primary aldosteronism is associated with excessive urinary albumin excretion compared to essential hypertension, which may indicate target-organ damage or proximal tubular impairment.

Albuminuria in untreated patients with primary aldosteronism or essential hypertension

Structured PICO

Discussion

Implication

Cite This Study

Topics

Albuminuria in untreated patients with primary aldosteronism or essential hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider