What does this research mean for the field?

AL amyloidosis can present with refractory ventricular fibrillation, but aggressive interventions such as VA-ECMO or ICDs may not provide a survival benefit due to the disease's poor overall prognosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2021Respiratory Medicine Case ReportsOpen Access

A case of AL amyloidosis presenting with refractory ventricular fibrillation

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Structured PICO

Population

66-year-old male with hypertension, heterozygous factor V Leiden mutation, and newly diagnosed heart failure with reduced ejection fraction, presenting with cardiogenic/vasodilatory shock and refractory ventricular fibrillation due to Mayo stage IV immunoglobulin light chain (AL) amyloidosis.

Intervention

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support

VA-ECMO can temporarily stabilize hemodynamics in patients with AL amyloidosis presenting with refractory ventricular fibrillation, though its routine use is not recommended given the limited overall survival in advanced disease.

Discussion

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Implication

May allow short-term stabilization in refractory VF with AL amyloidosis; leaves open survival benefit in advanced disease.

Cite This Study

Angsubhakorn et al. (2021) studied this question.

synapsesocial.com/papers/6a197b99f9a68600c7d994de https://doi.org/10.1016/j.rmcr.2021.101349

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A case of AL amyloidosis presenting with refractory ventricular fibrillation

Structured PICO

Discussion

Implication

Cite This Study

A case of AL amyloidosis presenting with refractory ventricular fibrillation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider