Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Smooth muscle cells dissociated freshly from mouse portal vein (mPV) and whole mPV

Intervention

KCNQ channel blockers (XE991, chromanol 293B, and linopirdine)

Outcome

Voltage-dependent K+ currents, resting membrane potential, and spontaneous contractile activitysurrogate

KCNQ channels play an important role in governing cellular excitability in mouse portal vein smooth muscle cells.

No takes yet. Share an insight, caveat, or question.

Supports KCNQ role in mouse portal vein excitability; leaves open translation to human vascular disease.

Yeung et al. (2005) studied this question.

View Full Paper

Ask AI

Bookmark