Why the study?
Does severe hypoxia modulate potassium currents in isolated smooth muscle cells from large pulmonary arteries of the rabbit?
Population
Isolated smooth muscle cells and precontracted rings from large diameter pulmonary arteries of the rabbit
Comparison
Severe hypoxia (< 10 mmHg) vs Basal conditions (normoxia)
Design
Preclinical
Authors
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Isolated rabbit cell data warrant no clinical changes in hypoxia management; leaves open Ca2+-dependent K+ roles in intact pulmonary vasoconstriction.
Does severe hypoxia modulate potassium currents in isolated smooth muscle cells from large pulmonary arteries of the rabbit?
Severe hypoxia directly modulates potassium channel activity in pulmonary artery smooth muscle cells, increasing voltage-gated K+ currents in a calcium-dependent manner.
Bonnet et al. (1994) studied this question.
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