DNA was synthesized in vitro from a template of purified ovalbumin messenger RNA. The DNA product is complementary to a homogeneous sequence specific for ovalbumin. The amount of ovalbumin sequence in hen oviduct and hen liver DNA was measured by hybridization experiments and found to be 2 copies per diploid genome in both tissues, indicating that there is no selective amplification of ovalbumin genes in the tissue specialized for obalbumin synthesis.
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Sullivan et al. (1973) studied this question.
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