Answers are grounded in this paper and cite their sources.
The metabolism of estradiol in girls with anorexia nervosa was compared with obese subjects and normal weight, age and sex matched controls. Increasing body weight was accompanied by a sharp decrease in 2-hydroxylation of estradiol and an increase in 16alpha-hydroxylation. These metabolic changes are discussed in terms of the biological activity of 2-hydroxyestrone and estriol.
No takes yet. Share an insight, caveat, or question.
Fishman et al. (1975) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: