What question did this study set out to answer?

Determine whether human prefrontal cortex regions, specifically the middle frontal gyrus, activate during spatial working memory tasks adapted from primate studies.

August 30, 1994Proceedings of the National Academy of SciencesOpen Access

Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task.

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Determine whether human prefrontal cortex regions, specifically the middle frontal gyrus, activate during spatial working memory tasks adapted from primate studies.
Measured brain activation using high-speed functional MRI in 8 subjects performing a sequential spatial working memory task with 14 or 15 stimulus locations.
Administered visual control tasks requiring the detection of red stimulus markers or briefly flashed dots with identical timing and stimulus sequences.
Repeated functional imaging protocols in 5 subjects to assess the consistency and replicability of cortical activation patterns.
MR signal increased specifically in the middle frontal gyrus (Brodmann's area 46) across all 8 subjects during the spatial working memory task, showing greater and more consistent activation in the right hemisphere.
Signal increases emerged within 6 to 9 seconds after task onset, resolved within 6 to 9 seconds post-task, and demonstrated greater magnitude than increases observed during control tasks.
Regional activation differences between working memory and control conditions were replicated upon retesting in 5 subjects.

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Implication

Functional MRI study reveals localized activation of the middle frontal gyrus during spatial working memory in humans, indicating conserved prefrontal organization across primates.

Cite This Study

McCarthy et al. (1994) studied this question.

synapsesocial.com/papers/6a19847cf3c200df10587cb3 https://doi.org/10.1073/pnas.91.18.8690

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Implication

Functional MRI study reveals localized activation of the middle frontal gyrus during spatial working memory in humans, indicating conserved prefrontal organization across primates.

Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task.

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Discussion

Implication

Cite This Study

Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task.

Key Points

Discussion

Implication

Cite This Study

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