Why the study?
Does a high-salt diet alter AT1 and ACE mRNA expression in angiotensinogen gene-knockout mice?
Does a high-salt diet alter AT1 and ACE mRNA expression in angiotensinogen gene-knockout mice?
Expression of AT1 and ACE is regulated by salt loading in a tissue-specific manner that appears to be mediated partly by mechanisms other than changes in angiotensin peptide levels.
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Hypothesis-generating for angiotensin-independent AT1 regulation by salt in mice; does not inform clinical practice.
Tamura et al. (1999) studied this question.
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