Key result
In mice, increasing the number of functional copies of the angiotensinogen gene resulted in significant and almost linear increases in blood pressure of approximately 8 mmHg per gene copy.
Why the study?
Does altering the number of functional copies of the angiotensinogen gene change blood pressure in mice?
Does altering the number of functional copies of the angiotensinogen gene change blood pressure in mice?
Effect estimate: 8.3 mmHg per copy
p-value: p=<0.01
This study establishes a direct causal relationship between angiotensinogen gene copy number and blood pressure, demonstrating that genetic variants altering plasma angiotensinogen levels directly affect blood pressure.
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Supports causal angiotensinogen gene dosage effects on BP in mice; leaves open human genetic relevance.
Kim et al. (1995) studied Hypertension (n=65). Altered copy number of the angiotensinogen (Agt) gene vs. 2 copies (wild-type) was evaluated on Mean arterial pressure (8.3 mmHg per copy, p=<0.01). In mice, increasing the number of functional copies of the angiotensinogen gene resulted in significant and almost linear increases in blood pressure of approximately 8 mmHg per gene copy.
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