Population
Mice (gene targeting experiments) and computer simulations of the renin-angiotensin system
Comparison
Gene targeting to vary the amounts of… vs Different levels of gene expression
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports angiotensinogen as BP regulator but not moderate ACE changes in mice; hypothesis-generating for human hypertension therapies.
Structured PICO
P
Population
Mice (gene targeting experiments) and computer simulations of the renin-angiotensin system
I
Intervention
Gene targeting to vary the amounts of angiotensinogen (Agt) and angiotensin-converting enzyme (ACE) synthesized from their genes
C
Comparator
Different levels of gene expression (gene titration)
O
Outcome
Blood pressure and steady state levels of angiotensin I (Ang I) and angiotensin II (Ang II)surrogate
Gene titration experiments in mice demonstrate that blood pressure is sensitive to changes in angiotensinogen expression but not to moderate changes in ACE expression, a finding supported by computer simulations.
Cite This Study
Oliver Smithies (1997) studied this question.