Why the study?
Does genetic titration of angiotensinogen gene expression alter the expression of hypertension-related genes and blood pressure in mice?
Does genetic titration of angiotensinogen gene expression alter the expression of hypertension-related genes and blood pressure in mice?
Moderate alterations in angiotensinogen gene expression induce significant, sex-specific changes in the expression of hypertension-related genes and blood pressure in mice.
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Does not inform human hypertension care; leaves open sex-specific angiotensinogen effects in preclinical models.
Kim et al. (2002) studied this question.
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