Angiotensinogen Genotype Affects Renal and Adrenal Responses to Angiotensin II in Essential Hypertension
Why the study?
Does angiotensinogen genotype affect renal and adrenal responses to infused Angiotensin II in hypertensive patients?
Population
190 hypertensive patients on carefully controlled high- and low-salt diets
Comparison
Angiotensin II infusion for 45 minutes vs Comparison across angiotensinogen genotypes
Design
Cross-sectional
Follow-up
45 minutes
Authors
Discussion
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Member takes
Implication
Does not support routine AGT genotyping in hypertension; leaves open genotype-stratified RAS inhibitor trials.
Structured PICO
Does angiotensinogen genotype affect renal and adrenal responses to infused Angiotensin II in hypertensive patients?
P
Population
190 hypertensive patients on carefully controlled high- and low-salt diets
I
Intervention
Angiotensin II infusion (3 ng/kg/min) for 45 minutes
C
Comparator
Comparison across angiotensinogen (AGT) genotypes (specifically presence of -6A allele)
O
Outcome
Renal plasma flow and plasma aldosterone responses to Angiotensin II infusionsurrogate
The AGT -6A genotype is associated with blunted renal and adrenal responses to infused Angiotensin II in hypertensive patients, suggesting higher baseline tissue renin-angiotensin system activity.
Cite This Study
Hopkins et al. (2002) studied this question.