What does this research mean for the field?

Angiotensin-converting enzyme (ACE) is essential for maintaining normal blood pressure, with its complete absence causing severe hypotension, whereas heterozygous reduction is compensated by increased renin expression to maintain baseline blood pressure despite altered responses to angiotensin I and bradykinin. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1997Hypertension

Blood Pressures and Cardiovascular Homeostasis in Mice Having Reduced or Absent Angiotensin-Converting Enzyme Gene Function

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Why the study?

Does insertional inactivation of the ACE gene reduce mean arterial pressure in mice?

Structured PICO

Does insertional inactivation of the ACE gene reduce mean arterial pressure in mice?

Population

Mice with wild-type (+/+), heterozygous (+/-), and homozygous mutant (-/-) genotypes for an insertional inactivation of the angiotensin-converting enzyme (ACE) gene

Intervention

Heterozygous (+/-) or homozygous (-/-) insertional inactivation of the ACE gene

Comparator

Wild-type (+/+) mice

Outcome

Baseline mean arterial pressuresurrogate

ACE is essential for maintaining normal blood pressure, and its absence significantly reduces mean arterial pressure and abolishes the pressor response to angiotensin I in a mouse model.

Discussion

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Implication

ACE inactivation lowers BP in mice; hypothesis-generating and should not change clinical practice.

Cite This Study

Tian et al. (1997) studied this question.

synapsesocial.com/papers/6a1bb02227b545b111a8e295 https://doi.org/10.1161/01.hyp.30.1.128

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Blood Pressures and Cardiovascular Homeostasis in Mice Having Reduced or Absent Angiotensin-Converting Enzyme Gene Function

Structured PICO

Discussion

Implication

Cite This Study

Blood Pressures and Cardiovascular Homeostasis in Mice Having Reduced or Absent Angiotensin-Converting Enzyme Gene Function

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider