Key result
Targeted cardiac ACE expression increasing ventricular angiotensin II twofold in mice did not produce cardiac dysfunction under basal conditions or augment cardiac hypertrophy after aortic banding.
Why the study?
Does increased local cardiac angiotensin II production promote cardiac hypertrophy or dysfunction in mice?
Population
Compound heterozygous mice with targeted ACE expression to the heart, wild-type mice, and previous ACE 8/8…
Comparison
Targeted cardiac ACE expression resulting in… vs Wild-type controls
Design
Preclinical
Follow-up
Evaluated at 6 months of age
Authors
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Moderate local Ang II elevation does not drive dysfunction or hypertrophy in mice; leaves open dose-, context-, or species-specific effects.
Does increased local cardiac angiotensin II production promote cardiac hypertrophy or dysfunction in mice?
A moderate increase in local cardiac angiotensin II production does not produce cardiac dysfunction or augment pressure overload-induced cardiac hypertrophy in mice.
Xiao et al. (2007) studied Cardiac hypertrophy. Targeted cardiac ACE expression (ACE 1/8 genotype) vs. Wild-type mice was evaluated on Cardiac hypertrophy and cardiac function. Targeted cardiac ACE expression increasing ventricular angiotensin II twofold in mice did not produce cardiac dysfunction under basal conditions or augment cardiac hypertrophy after aortic banding.
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