February 1, 2003HypertensionOpen Access

Mice Lacking Endothelial ACE

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Population

ACE 1/3 mice and wild-type control mice

Comparison

2 weeks of a salt-free diet vs Wild-type control mice

Design

Preclinical

Follow-up

2 weeks

Authors

JCJustin M. ColeUniversity of South Florida NKNata KhokhlovaHoward Hughes Medical Institute RSRoy L. SutliffNational Institutes of Health

Discussion

Member takes

Implication

Highlights endothelial ACE compensation under basal conditions but vulnerability to salt depletion; leaves open translation to human hypertension.

Structured PICO

Population

ACE 1/3 mice (one allele of ACE is null and the second allele engineered to express ACE on the surface of hepatocytes, lacking endothelial and lung ACE) and wild-type control mice

Intervention

2 weeks of a salt-free diet (a stress diet stimulating the renin-angiotensin system)

Comparator

Wild-type control mice

Outcome

Blood pressuresurrogate

Mice lacking endothelial ACE maintain normal basal blood pressure through significant compensation but exhibit a significant decrease in blood pressure when stressed with a salt-free diet.

Cite This Study

Cole et al. (2003) studied this question.

synapsesocial.com/papers/6a70fb0f75498292b70a7793 https://doi.org/10.1161/01.hyp.0000050650.52007.83

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February 1, 2003HypertensionOpen Access

Mice Lacking Endothelial ACE

View Full Paper

Ask AI

Bookmark

Population

ACE 1/3 mice and wild-type control mice

Comparison

2 weeks of a salt-free diet vs Wild-type control mice

Design

Preclinical

Follow-up

2 weeks

Authors

JCJustin M. ColeUniversity of South Florida NKNata KhokhlovaHoward Hughes Medical Institute RSRoy L. SutliffNational Institutes of Health

Discussion

Member takes

Implication

Highlights endothelial ACE compensation under basal conditions but vulnerability to salt depletion; leaves open translation to human hypertension.

Structured PICO

Population

ACE 1/3 mice (one allele of ACE is null and the second allele engineered to express ACE on the surface of hepatocytes, lacking endothelial and lung ACE) and wild-type control mice

Intervention

2 weeks of a salt-free diet (a stress diet stimulating the renin-angiotensin system)

Comparator

Wild-type control mice

Outcome

Blood pressuresurrogate

Mice lacking endothelial ACE maintain normal basal blood pressure through significant compensation but exhibit a significant decrease in blood pressure when stressed with a salt-free diet.

Cite This Study

Cole et al. (2003) studied this question.

synapsesocial.com/papers/6a70fb0f75498292b70a7793 https://doi.org/10.1161/01.hyp.0000050650.52007.83

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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