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January 11, 2002Circulation Research

Mice Lacking Endothelial Angiotensin-Converting Enzyme Have a Normal Blood Pressure

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Why the study?

Does the lack of endothelial ACE alter blood pressure and renal function in mice?

Population

Genetically altered mice lacking endothelial ACE (ACE.3(-/-) mice)

Comparison

Targeted homologous recombination to separate… vs Littermate wild-type mice

Design

Preclinical

Authors

JCJustin M. ColeUniversity of South FloridaDQDu Le QuachHoward Hughes Medical InstituteKSKarthik M. SundaramHospital of the University of Pennsylvania

Discussion

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Implication

Endothelial ACE is dispensable for basal BP and renal function in mice; leaves open its role in human hypertension or kidney disease.

Structured PICO

Does the lack of endothelial ACE alter blood pressure and renal function in mice?

P
Population
Genetically altered mice lacking endothelial ACE (ACE.3(-/-) mice)
I
Intervention
Targeted homologous recombination to separate transcriptional control of somatic ACE from its endogenous promoter and substitute control to the albumin promoter, resulting in lack of endothelial ACE
C
Comparator
Littermate wild-type mice
O
Outcome
Blood pressuresurrogate

Under basal conditions, the normal regulation of blood pressure and renal function is possible in a mouse devoid of endothelial ACE.

Cite This Study

Cole et al. (2002) studied this question.

synapsesocial.com/papers/6a856aa211a1f3349d109bfehttps://doi.org/10.1161/hh0102.102360
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic control of blood pressure and the angiotensinogen locus.1995 · 643 citations
  2. 2Vascular Angiotensin-Converting Enzyme Expression Regulates Local Angiotensin II1997 · 98 citations
  3. 3Angiotensin-Converting Enzyme Gene Polymorphism Has No Influence on the Circulating Renin-Angiotensin-Aldosterone System or Blood Pressure in Normotensive Subjects1995 · 147 citations
  4. 4A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice1995 · 595 citations
  5. 5The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.1997 · 277 citations