Population
Mice having one, two, or three functional copies of the Ace gene at its normal chromosomal location (n=132)
Comparison
One or three functional copies of the Ace gene vs Normal two-copy mice
Design
Preclinical
Authors
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ACE gene dosage alters activity without BP change in mice; leaves open compensatory mechanisms and human hypertension relevance.
Quantitative changes in Ace gene expression do not significantly alter blood pressure in mice due to homeostatic adaptations, suggesting additional environmental or genetic factors are required to exceed homeostatic capacity.
Krege et al. (1997) studied this question.
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