February 1, 2002Hypertension
Blood Pressure and NaCl-Sensitive Hypertension Are Influenced by Angiotensin-Converting Enzyme Gene Expression in Transgenic Mice
Why the study?
Does ACE gene copy number influence basal arterial pressure and the blood pressure response to a high-NaCl diet in female transgenic mice?
Population
Female transgenic mice with partial or complete deletion of the ACE gene, and wild-type mice
Comparison
High-NaCl diet vs Basal NaCl diet
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not alter clinical hypertension management; extends preclinical models of ACE dosage in salt-sensitive BP.
Structured PICO
Does ACE gene copy number influence basal arterial pressure and the blood pressure response to a high-NaCl diet in female transgenic mice?
P
Population
Female transgenic mice with partial (1-copy) or complete (0-copy) deletion of the ACE gene, and wild-type (2-copy) mice
I
Intervention
High-NaCl diet
C
Comparator
Basal NaCl diet
O
Outcome
24-hour mean arterial pressuresurrogate
There is a copy-dependent relationship between ACE gene expression and both basal arterial pressure and salt-sensitive hypertension in mice.
Cite This Study
Carlson et al. (2002) studied this question.