What does this research mean for the field?

C-type natriuretic peptide (CNP) exerts a significant, prolonged, and direct positive chronotropic effect on the heart that is independent of major autonomic and local receptor pathways, whereas atrial natriuretic peptide (ANP) has no significant effect on basal sinus rate. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1996British Journal of PharmacologyOpen Access

Direct chronotropic effects of atrial and C‐type natriuretic peptides in anaesthetized dogs

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Population

21 anaesthetized and vagotomized dogs pretreated with a beta-adrenoceptor antagonist and spontaneously…

Comparison

Atrial natriuretic peptide and C-type… vs Basal sinus rate (pre-injection levels)

Design

Preclinical

Follow-up

up to 17 +/- 3 min post-injection

Authors

PBPierre BeaulieuInstitute for Research in Immunology and Cancer RCRené CardinalHôpital du Sacré-Cœur de Montréal ALAndré De LéanUniversité de Montréal

Discussion

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Implication

CNP chronotropy in canine models prompts targeted human studies; leaves open any clinical relevance or therapeutic implications.

Structured PICO

Population

21 anaesthetized and vagotomized dogs pretreated with a beta-adrenoceptor antagonist (in vivo) and spontaneously beating right atria isolated from 6 dogs (in vitro)

Intervention

Atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) injections (50 micrograms in 1 ml of Tyrode solution as bolus over 1 min) directly into the sinus node artery

Comparator

Basal sinus rate (pre-injection levels)

Outcome

Change in sinus rate (chronotropic effect)surrogate

CNP exerts a significant and prolonged positive chronotropic effect in vivo and in vitro in dog models.

Cite This Study

Beaulieu et al. (1996) studied this question.

synapsesocial.com/papers/6a198a468ef0a4da5e8dfa65 https://doi.org/10.1111/j.1476-5381.1996.tb15605.x

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Direct chronotropic effects of atrial and C‐type natriuretic peptides in anaesthetized dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Direct chronotropic effects of atrial and C‐type natriuretic peptides in anaesthetized dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider