Why the study?
Newly diagnosed iPAH patients increasingly have risk factors for left ventricular diastolic dysfunction, which may affect management and treatment.
Does a high H2FPEF-score identify a subgroup of iPAH patients with a blunted response to PAH-targeted treatment?
Population
iPAH patients from the Amsterdam UMC PAH-cohort
Comparison
H2FPEF-score ≥5 vs lower scores
Design
Cohort study
Authors
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May warrant closer monitoring in high-score iPAH; leaves open prospective validation of score-guided management.
Does a high H2FPEF-score identify a subgroup of iPAH patients with a blunted response to PAH-targeted treatment?
A high H2FPEF-score (≥5) may identify iPAH patients with concealed left ventricular diastolic dysfunction who have a blunted response to PAH-targeted therapies.
Kianzad et al. (2022) studied this question.
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