Why the study?
Does aspirin 100 mg/d administered at different times of day reduce blood pressure in pregnant women at risk for preeclampsia?
Population
240 pregnant women at differing risk of developing hypertension in pregnancy
Comparison
Aspirin 100 mg/d starting at 12 to 16 weeks of… vs Matching placebo administered at the same times
Design
RCT, Randomly assigned to 1 of 6 groups according to treatment and time of…
Follow-up
Until puerperium (6 to 8 weeks after delivery)
Authors
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Bedtime low-dose aspirin may be preferred for BP control in preeclampsia-risk pregnancies; extends chronotherapy evidence from prior trials.
Does aspirin 100 mg/d administered at different times of day reduce blood pressure in pregnant women at risk for preeclampsia?
Low-dose aspirin significantly reduces blood pressure in pregnant women at risk for hypertensive complications when administered before bedtime, but not upon awakening.
Hermida et al. (1999) studied this question.
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