What does this research mean for the field?

Adenosine A1, A2A, and A2B receptors are required for statin-induced ERK1/2 activation, which subsequently leads to the phosphorylation and activation of Akt and eNOS. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 7, 2007AJP Heart and Circulatory Physiology

The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation

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Authors

RMRamanna MerlaPomona Valley Hospital Medical Center YYYumei YeShanghai Jiao Tong University YLYu LinThe University of Texas MD Anderson Cancer Center

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Implication

Adenosine receptor blockade attenuates atorvastatin-induced Akt/eNOS phosphorylation in rodents; leaves open translation to clinical statin benefits.

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Cite This Study

Merla et al. (2007) studied this question.

synapsesocial.com/papers/6a19902b60e90a7f5fea6700 https://doi.org/10.1152/ajpheart.00416.2007

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PCSK9 inhibitors Statin therapy

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Implication

Adenosine receptor blockade attenuates atorvastatin-induced Akt/eNOS phosphorylation in rodents; leaves open translation to clinical statin benefits.

The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation

Discussion

Member takes

Implication

Key Points

Cite This Study

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