Why the study?
The optimal revascularization strategy for diabetic patients with coronary artery disease remains controversial between PCI with drug-eluting stents and bypass grafting.
Does percutaneous coronary intervention with drug-eluting stents reduce major adverse cardiovascular events compared to coronary artery bypass grafting in diabetic patients with multivessel and/or left main coronary artery disease?
Does percutaneous coronary intervention with drug-eluting stents reduce major adverse cardiovascular events compared to coronary artery bypass grafting in diabetic patients with multivessel and/or left main coronary artery disease?
In diabetic patients with multivessel or left main coronary artery disease, CABG is superior to PCI-DES for reducing MACCEs, MACEs, myocardial infarction, stroke, and repeat revascularization, though all-cause mortality is comparable.
Answers are grounded in this paper and cite their sources.
Supports preferring CABG over PCI-DES in diabetics with multivessel/LM disease; confirms superiority for reducing MACEs.
Although percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) and bypass grafting are generally believed to be superior revascularization strategies in patients with coronary artery disease (CAD), the optimal strategy for diabetic patients is still controversial. This meta-analysis was performed to compare two methods of revascularization for patients with diabetes mellitus with left main coronary artery lesions or disease in multiple coronary arteries. Compared with the coronary artery bypass grafting (CABG) group, those receiving PCI-DES showed a greater risk of major adverse cardiovascular events (MACEs) (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.01-1.25, P = 0.03), major adverse cardiac and cerebrovascular events (MACCEs) (HR: 1.85, 95% CI: 1.58-2.16; P < 0.001), stroke (HR: 1.15, 95% CI: 1.02-1.29, P = 0.02), myocardial infarction (MI) (HR: 1.48, 95% CI: 1.04-2.09, P = 0.03), and repeat revascularization (HR: 3.23, 95% CI: 1.37-7.59, P = 0.007). CABG for diabetic patients with multivessel and/or left main CAD was superior to PCI-DES with regard to MACEs, MACCEs, MI, repeat revascularization and stroke, but there was no clear difference in all-cause mortality.
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Xin et al. (2019) studied this question.
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