What question did this study set out to answer?

To compare clinical outcomes between drug-eluting stent percutaneous coronary intervention and coronary artery bypass grafting in patients with multivessel coronary disease.

April 27, 2009European Journal of Cardio-Thoracic SurgeryOpen Access

Coronary artery bypass grafting versus drug-eluting stents in multivessel coronary disease. A meta-analysis on 24,268 patients☆

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To compare clinical outcomes between drug-eluting stent percutaneous coronary intervention and coronary artery bypass grafting in patients with multivessel coronary disease.
Conducted a systematic literature search of observational cohort studies comparing DES-PCI versus CABG in multivessel coronary disease.
Analyzed 9 observational nonrandomized studies including 24,268 patients (DES-PCI: n=13,540; CABG: n=10,728) with a mean follow-up of 20 months.
Calculated pooled hazard ratios for clinical outcomes using mixed model methodology.
Composite incidence of death, acute myocardial infarction, and cerebrovascular accidents was similar between groups (HR=0.94; 95% CI=0.72-1.22; p=0.66).
Repeat revascularization was significantly more frequent with DES-PCI compared with CABG (HR=4.06; 95% CI=2.64-6.24; p<0.001).
Overall major adverse cardiac and cerebrovascular event rates were significantly higher in the DES-PCI cohort (HR=1.86; 95% CI=1.36-2.54; p<0.001).

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Implication

Meta-analysis reveals higher major adverse events after drug-eluting stents than bypass surgery in multivessel coronary disease, indicating increased need for repeat revascularization.

Cite This Study

Benedetto et al. (2009) studied this question.

synapsesocial.com/papers/6a758a32e2440913015ffe5a https://doi.org/10.1016/j.ejcts.2009.03.012

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Implication

Meta-analysis reveals higher major adverse events after drug-eluting stents than bypass surgery in multivessel coronary disease, indicating increased need for repeat revascularization.

Coronary artery bypass grafting versus drug-eluting stents in multivessel coronary disease. A meta-analysis on 24,268 patients☆

Key Points

Discussion

Implication

Cite This Study

Coronary artery bypass grafting versus drug-eluting stents in multivessel coronary disease. A meta-analysis on 24,268 patients☆

Key Points

Discussion

Implication

Cite This Study

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