What question did this study set out to answer?

To investigate the induction patterns and pharmacological mechanisms of homosynaptic long-term depression and slow-onset long-term potentiation at perforant path-dentate gyrus synapses in vivo.

December 12, 2013Journal of Neurophysiology

Low-frequency stimulation induces long-term depression and slow onset long-term potentiation at perforant path-dentate gyrus synapses in vivo

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Authors

JGJossina GonzalezThe University of Texas Health Science Center at San Antonio IMIsaiah S. MoralesThe University of Texas Health Science Center at San Antonio DVDesiree M. VillarrealThe University of Texas Health Science Center at San Antonio

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Implication

In vivo study reveals low-frequency stimulation induces slow-onset potentiation and variable depression in rat dentate gyrus, indicating surgical trauma alters synaptic plasticity mechanisms.

Key Points

To investigate the induction patterns and pharmacological mechanisms of homosynaptic long-term depression and slow-onset long-term potentiation at perforant path-dentate gyrus synapses in vivo.
Delivered low-frequency stimulation (900 pulses at 1 Hz) and paired-pulse stimulation (900 pairs, 200-ms interval) to lateral and medial perforant paths in freely moving and anesthetized rats.
Administered the NMDA receptor antagonist CPP (10 mg/kg) systemically 90 minutes prior to stimulation to evaluate receptor dependency.
Compared synaptic plasticity outcomes following acute surgical electrode implantation versus chronic implantation in recovered animals.
Low-frequency stimulation after acute implantation induced slow-onset LTP at both pathways, with medial perforant path LTP blocked by CPP (NMDA receptor-dependent) and lateral perforant path LTP unaffected (NMDA receptor-independent).
Paired-pulse low-frequency stimulation produced rapid-onset LTP in the lateral perforant path, whereas it produced slow-onset LTP in the medial perforant path.
Homosynaptic LTD occurred inconsistently in freely moving rats and was rarely observed after acute electrode placement, appearing primarily in surgically recovered animals.

Cite This Study

Gonzalez et al. (2013) studied this question.

synapsesocial.com/papers/6a1995ce0ad3341a9fea64d1 https://doi.org/10.1152/jn.00941.2012

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Implication

In vivo study reveals low-frequency stimulation induces slow-onset potentiation and variable depression in rat dentate gyrus, indicating surgical trauma alters synaptic plasticity mechanisms.

Low-frequency stimulation induces long-term depression and slow onset long-term potentiation at perforant path-dentate gyrus synapses in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

Low-frequency stimulation induces long-term depression and slow onset long-term potentiation at perforant path-dentate gyrus synapses in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

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