What question did this study set out to answer?

To identify novel CYP2C9 genetic variants and evaluate their impact on maintenance warfarin dose requirements across different Asian ethnic groups.

September 1, 2004Clinical Pharmacology & Therapeutics

Novel genetic variants in Asian subjects and their influence on maintenance warfarin dose

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Authors

FZFuqiang ZhaoTaiyuan University of Science and Technology CLChok K. LokeBeijing Normal University - Hong Kong Baptist University United International College SRS RANKINNational University of Singapore

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Implication

Prospective study uncovers novel CYP2C9 variants and ethnic dosing disparities in Asian patients, indicating that non-coding or environmental factors drive maintenance requirements.

Key Points

To identify novel CYP2C9 genetic variants and evaluate their impact on maintenance warfarin dose requirements across different Asian ethnic groups.
Prospectively enrolled 125 patients receiving a stable maintenance warfarin dose targeting an international normalized ratio between 2 and 3.
Performed comprehensive DNA sequencing across the promoter and coding regions of the CYP2C9 gene.
Mean weight-adjusted warfarin maintenance dose was significantly lower for Malay (P < .001) and Chinese (P = .014) patients compared to Indian patients, with dose negatively correlating with age (r = -0.4, P < .001) but not sex.
Identified 16 novel CYP2C9 variants, including 7 nonsynonymous exonic variants (208G>C, 374G>A, 485C>A, 895A>G, 1144C>T, 1190A>C, and 1362G>C).
CYP2C9*3 carriers required lower warfarin doses among Chinese (P < .01) and Indian (P < .01) patients but not Malay patients (P = .77), and dose differences between ethnic groups persisted after excluding patients with coding-region variants.

Cite This Study

Zhao et al. (2004) studied this question.

synapsesocial.com/papers/6a1996cf3e4c9aaeb7f64625 https://doi.org/10.1016/j.clpt.2004.05.005

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Implication

Prospective study uncovers novel CYP2C9 variants and ethnic dosing disparities in Asian patients, indicating that non-coding or environmental factors drive maintenance requirements.

Novel genetic variants in Asian subjects and their influence on maintenance warfarin dose

Discussion

Member takes

Implication

Key Points

Cite This Study

Novel genetic variants in Asian subjects and their influence on maintenance warfarin dose

Discussion

Member takes

Implication

Key Points

Cite This Study

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