What question did this study set out to answer?

To determine whether chemoprophylaxis and chemotherapy can control recurrent infection, delay disease progression, and preserve ventilatory function in early chronic bronchitis.

May 28, 1966BMJOpen Access

Value of chemoprophylaxis and chemotherapy in early chronic bronchitis. A report to the Medical Research Council by their working party on trials of chemotherapy in early chronic bronchitis.

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Implication

Controlled double-blind trial reports illness frequency and lung function trends in early chronic bronchitis, highlighting recruitment challenges in early disease.

Key Points

To determine whether chemoprophylaxis and chemotherapy can control recurrent infection, delay disease progression, and preserve ventilatory function in early chronic bronchitis.
Multicenter, controlled double-blind trial across 13 chest clinics in the UK following employed men aged 40–59 over a five-year period.
Eligible participants required grade 2 productive cough, at least two chest illnesses causing ≥3 weeks work absence in the previous 3 years, and a forced expiratory volume in one second (FEV1) > 1.4 L without other disabling conditions.
Intervention evaluated seasonal chemoprophylaxis using oxytetracycline (0.5 g once daily) administered from mid-September to mid-April.
Participant recruitment encountered substantial obstacles, with only one of 13 clinics achieving the target of 60 cases despite extending recruitment over two years.
Most clinic attendees with recurrent chest illnesses had an FEV1 below the 1.4 L cutoff, while those with FEV1 > 1.4 L experienced infrequent illnesses, leading to high exclusion rates.
Considerable variation occurred among participating clinics in the characteristics of subjects recruited for long-term follow-up.

Cite This Study

A 1966 study studied this question.

synapsesocial.com/papers/6a1997bd05af093a17f64c52 https://doi.org/10.1136/bmj.1.5499.1317

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Implication

Controlled double-blind trial reports illness frequency and lung function trends in early chronic bronchitis, highlighting recruitment challenges in early disease.

Value of chemoprophylaxis and chemotherapy in early chronic bronchitis. A report to the Medical Research Council by their working party on trials of chemotherapy in early chronic bronchitis.

Discussion

Member takes

Implication

Key Points

Cite This Study

Value of chemoprophylaxis and chemotherapy in early chronic bronchitis. A report to the Medical Research Council by their working party on trials of chemotherapy in early chronic bronchitis.

Discussion

Member takes

Implication

Key Points

Cite This Study

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