Mathematical modeling suggests that IKur blockers may be more effective in prolonging action potential duration in patients with atrial fibrillation, and combining IKur and IKr blockade has synergistic effects.
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May selectively prolong APD in AF-remodeled atria; leaves open clinical antiarrhythmic efficacy of IKur or combined blockade.
Marc Courtemanche (1999) studied this question.
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