Why the study?
Does anesthesia alter echocardiographically determined cardiac structure and function compared to the conscious state in normal and diseased mice?
Population
Mice (including wild-type, mice with cardiac overexpression of beta-adrenergic receptors, and mice with…
Comparison
Anesthesia with a mixture of ketamine and… vs Conscious state
Design
Preclinical
Authors
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Anesthesia may confound murine echocardiography; leaves open optimal protocols for diseased models.
Does anesthesia alter echocardiographically determined cardiac structure and function compared to the conscious state in normal and diseased mice?
The autonomic nervous system plays a critical role in the observed differences in cardiac structure and function between anesthetized and conscious mice, highlighting the importance of considering anesthetic effects in murine echocardiography.
Tan et al. (2003) studied this question.
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