Cellular Mechanisms of Myocardial Stunning

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Macrophage polarization is a dynamic and plastic process that integrates multiple environmental signals, such as those from microbes and damaged tissues. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Hideo Kusuoka; Eduardo Marbán

doi:10.1146/annurev.ph.54.030192.001331

October 1, 1992Annual Review of Physiology

Cellular Mechanisms of Myocardial Stunning

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Key Points

To examine the cellular mechanisms underlying myocardial stunning with an emphasis on how macrophages adapt and polarize in response to damaged tissue.
Literature review analyzing cellular activation pathways and physiological signals in damaged tissue environments.
Evaluation of macrophage plasticity and responsive polarization states driven by microbial and tissue injury cues.
Macrophage polarization represents a dynamic, non-fixed functional state influenced continuously by microenvironmental signals.
Injured tissue environments release diverse cellular signals that guide macrophage functional shifts during myocardial stress.

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Implication

Synthesizes macrophage polarization mechanisms in myocardial stunning; leaves open clinical translation pending targeted trials.

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Kusuoka et al. (1992) studied this question.

synapsesocial.com/papers/6a199a2043a2499ce8f64f5a https://doi.org/10.1146/annurev.ph.54.030192.001331

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Cellular Mechanisms of Myocardial Stunning

Key Points

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Implication

Abstract

Discussion

Cite This Study

Cellular Mechanisms of Myocardial Stunning

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Implication

Abstract

Discussion

Cite This Study

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