Why the study?
Does ranitidine reduce gastric mucosal bleeding in subjects taking low-dose aspirin?
Population
30 human subjects
Comparison
Aspirin 300 mg daily for 12 days with ranitidine… vs Aspirin 300 mg daily for 12 days without…
Follow-up
12 days
Authors
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May attenuate low-dose aspirin gastric bleeding; hypothesis-generating and should not yet change practice.
Does ranitidine reduce gastric mucosal bleeding in subjects taking low-dose aspirin?
Ranitidine coadministration significantly reduces gastric mucosal bleeding induced by low-dose aspirin, suggesting a potential prophylactic strategy against gastrointestinal hemorrhage.
Kitchingman et al. (1989) studied this question.
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