What question did this study set out to answer?

To quantitatively evaluate the regional pattern and time course of blood-brain barrier permeability alterations following transient middle cerebral artery occlusion.

November 1, 1996Brain ResearchOpen Access

Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats

View Full Paper

Ask AI

Bookmark

To quantitatively evaluate the regional pattern and time course of blood-brain barrier permeability alterations following transient middle cerebral artery occlusion.
Male Sprague-Dawley rats underwent 2 hours of transient middle cerebral artery occlusion using a poly-L-lysine-coated intraluminal nylon suture.
Blood-brain barrier permeability was measured via fluorometric quantitation of Evans Blue dye extravasation across six brain regions at 2, 3, 24, and 48 hours post-occlusion, alongside histopathological infarct volume assessment at 72 hours.
Evans Blue extravasation was absent at 2–3 hours but increased significantly in the ipsilateral hemisphere by 179% at 4 hours, 407% at 5 hours, 311% at 26 hours, and 264% at 50 hours (P < 0.05 vs. sham across all timepoints).
Histopathological evaluation at 72 hours revealed a mean cerebral infarction volume of 163.6 ± 7.7 mm³.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Preclinical study demonstrates biphasic blood-brain barrier opening in rats after middle cerebral artery occlusion, highlighting distinct windows for therapeutic intervention.

Cite This Study

Belayev et al. (1996) studied this question.

synapsesocial.com/papers/6a19a7d1443d3ecd7cdedc38 https://doi.org/10.1016/s0006-8993(96)00815-3

View Full Paper

Ask AI

Bookmark

Implication

Preclinical study demonstrates biphasic blood-brain barrier opening in rats after middle cerebral artery occlusion, highlighting distinct windows for therapeutic intervention.

Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats

Key Points

Discussion

Implication

Cite This Study

Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider