What does this research mean for the field?

Myosoft is a reliable, automated machine learning tool for muscle histology analysis that operates over 10 times faster than manual methods and outperforms existing programs on suboptimal images. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 4, 2020PLoS ONEOpen Access

Myosoft: An automated muscle histology analysis tool using machine learning algorithm utilizing FIJI/ImageJ software

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Population

Transverse sections of entire gastrocnemius/soleus muscles

Comparison

Myosoft automated analysis vs manual analysis and currently available programs

Authors

LELucas Encarnacion-RiveraHoward Hughes Medical Institute SFSteven FoltzRegenxbio (United States)HHH. Criss HartzellElectrophysiology

Discussion

Member takes

Implication

May expedite preclinical muscle histology workflows; leaves open validation for human cardiovascular research applications.

Structured PICO

Population

Transverse sections of entire gastrocnemius/soleus muscles stained for cell boundary (laminin) and myofiber type (myosin heavy chain isoforms)

Intervention

Myosoft automated muscle histology analysis tool using machine learning algorithm in FIJI/ImageJ

Comparator

Manual analysis and currently available comparable programs

Outcome

Accuracy and speed of myofiber size and type analysissurrogate

Myosoft is a reliable, high-throughput, and freely available tool for automated analysis of muscle histology that significantly outperforms manual analysis in speed.

Cite This Study

Encarnacion-Rivera et al. (2020) studied this question.

synapsesocial.com/papers/6a19a94c5085da102eea6294 https://doi.org/10.1371/journal.pone.0229041

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Myosoft: An automated muscle histology analysis tool using machine learning algorithm utilizing FIJI/ImageJ software

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myosoft: An automated muscle histology analysis tool using machine learning algorithm utilizing FIJI/ImageJ software

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider