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The surface-enhanced Raman scattering enhancement (SERS) of small molecules spatially entrapped near hot spots by using nanofluidic channels with localized surface plasmon resonance is reported. Small molecules are introduced into the interstitial nanogaps between a silver film over nanospheres and polydimethylsiloxane, which serve as ‘nanofluidic channels.’ The concurrence between nanofluid stagnation points and the hot spots greatly enhances the SERS signals.
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Oh et al. (2010) studied this question.
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