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New ways of detecting low concentrations of analytes , which could be used as part of integrated on‐chip devices, are offered by surface‐enhanced Raman‐scattering substrates fabricated on the nanoscale. The ability of metal surfaces to amplify a Raman‐scattering signal (see Figure) is combined with an enlarged substrate surface area, allowing orders of magnitude enhancement for the detection of rhodamine 6G and adenine.
Chan et al. (Thu,) studied this question.