What does this research mean for the field?

A novel lipoprotein pathology, A-IMilano, is characterized by severe hypertriglyceridemia, markedly reduced HDL-cholesterol, and apoprotein-A-I abnormalities, yet presents without clinical signs of atherosclerosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

November 1, 1980Journal of Clinical InvestigationOpen Access

A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family.

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Population

3 members of an Italian family with significant hypertriglyceridemia and very marked decrease of high…

Design

Case_series

Authors

GFGuido FranceschiniUniversità Cattolica del Sacro Cuore CSCesare R. SirtoriGeneral / Preventive / Lipids ACAntonio CapursoUniversity of Bari Aldo Moro

Discussion

Member takes

Implication

ApoA-I variants may not increase atherosclerotic risk despite profound HDL deficiency; hypothesis-generating for HDL functionality over quantity in CVD protection.

Structured PICO

Population

3 members (father, son, and daughter) of an Italian family with significant hypertriglyceridemia and very marked decrease of high density lipoproteins (HDL)-cholesterol levels

Comparator

Normal subjects (for lipoprotein morphology and composition comparisons)

Outcome

Lipoprotein modifications, HDL-cholesterol levels, and presence of clinical atherosclerosissurrogate

The study identifies a novel lipoprotein pathology (A-IMilano) characterized by severe HDL deficiency and apoprotein abnormalities that paradoxically does not lead to clinical atherosclerosis.

Cite This Study

Franceschini et al. (1980) studied this question.

synapsesocial.com/papers/6a19acc33f3ec013f0dee885 https://doi.org/10.1172/jci109956

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Implication

ApoA-I variants may not increase atherosclerotic risk despite profound HDL deficiency; hypothesis-generating for HDL functionality over quantity in CVD protection.

A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider