What does this research mean for the field?

High levels of circulating angiotensin II increase the minimum values of arterial pressure, sympathetic nerve activity, and heart rate without attenuating the response range or maximum gain of the open-loop carotid sinus baroreflex in anesthetized rats. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 17, 2009The Journal of Physiological SciencesOpen Access

High levels of circulating angiotensin II shift the open-loop baroreflex control of splanchnic sympathetic nerve activity, heart rate and arterial pressure in anesthetized rats

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Population

Anesthetized and vagotomized rats

Comparison

Intravenous angiotensin II (10 microg kg h) vs Control state (implied by comparative values)

Design

Preclinical

Authors

TKToru KawadaUniversity of Chichester AKAtsunori KamiyaHeart Failure & Transplant MLMeihua LiNational Cerebral and Cardiovascular Center

Discussion

Member takes

Implication

ANG II resets baroreflex operating point upward without blunting sensitivity in rats; leaves open translation to human hypertension.

Structured PICO

Population

Anesthetized and vagotomized rats

Intervention

Intravenous angiotensin II (10 microg kg(-1) h(-1))

Comparator

Control state (implied by comparative values)

Outcome

Steady-state responses in systemic arterial pressure (AP), splanchnic sympathetic nerve activity (SNA), and heart rate (HR) to changes in carotid sinus pressuresurrogate

High levels of circulating angiotensin II shift the operating point of the baroreflex to higher pressures, sympathetic activity, and heart rates without attenuating its sensitivity or response range in rats.

Cite This Study

Kawada et al. (2009) studied this question.

synapsesocial.com/papers/6a19b09b3f3ec013f0deed55 https://doi.org/10.1007/s12576-009-0055-5

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High levels of circulating angiotensin II shift the open-loop baroreflex control of splanchnic sympathetic nerve activity, heart rate and arterial pressure in anesthetized rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High levels of circulating angiotensin II shift the open-loop baroreflex control of splanchnic sympathetic nerve activity, heart rate and arterial pressure in anesthetized rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider