What does this research mean for the field?

Rapid expansion of the lungs activates afferent nerves that inhibit the cardiodepressor reflexes (decreases in heart rate) normally evoked by carotid baroreceptor or chemoreceptor stimulation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1978The Journal of PhysiologyOpen Access

Inhibition of baroreceptor and chemoreceptor reflexes on heart rate by afferents from the lungs.

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Population

Dogs anaesthetized with chloralose and paralysed with D-turbocurarine

Comparison

Lung inflation during baroreceptor or… vs Baroreceptor or chemoreceptor stimulation when…

Design

Preclinical

Authors

SGSimon C. GandeviaUniversity of Delhi DMD.I. McCloskeyNeuroscience Research Australia EPErica K. PotterThe University of Sydney

Discussion

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Implication

Lung afferents may inhibit reflex bradycardia in animals; leaves open translation to human cardiopulmonary physiology.

Structured PICO

Population

Dogs anaesthetized with chloralose and paralysed with D-turbocurarine

Intervention

Lung inflation (rapid increase in intratracheal pressure) during baroreceptor or chemoreceptor stimulation

Comparator

Baroreceptor or chemoreceptor stimulation when lung volume is not changing, or after surgical denervation of the lungs

Outcome

Changes in heart ratesurrogate

This preclinical study demonstrates that lung inflation inhibits the cardiodepressor reflexes triggered by baroreceptor and chemoreceptor stimulation via lung afferents.

Cite This Study

Gandevia et al. (1978) studied this question.

synapsesocial.com/papers/6a19b09f3f3ec013f0deed6b https://doi.org/10.1113/jphysiol.1978.sp012240

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Inhibition of baroreceptor and chemoreceptor reflexes on heart rate by afferents from the lungs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of baroreceptor and chemoreceptor reflexes on heart rate by afferents from the lungs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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