Chronic Endothelin-1 Treatment Leads to Insulin Resistance In Vivo
Why the study?
Does chronic endothelin-1 treatment lead to insulin resistance in WKY rats?
Population
WKY rats (male and female normal rats) and isolated soleus muscle strips
Comparison
Chronic endothelin-1 treatment via osmotic… vs Untreated/control rats or muscle strips
Design
Preclinical
Follow-up
5 days
Authors
Discussion
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Member takes
Implication
No immediate clinical implications; leaves open endothelin-1 as a therapeutic target in human insulin resistance.
Structured PICO
Does chronic endothelin-1 treatment lead to insulin resistance in WKY rats?
P
Population
WKY rats (male and female normal rats) and isolated soleus muscle strips
I
Intervention
Chronic endothelin-1 (ET-1) treatment via osmotic minipumps for 5 days (in vivo); ET-1 pretreatment for 1 hour (in vitro)
C
Comparator
Untreated/control rats or muscle strips
O
Outcome
Insulin-stimulated glucose disposal rates (in vivo) and glucose transport in skeletal muscle strips (in vitro/ex vivo)surrogate
Chronic endothelin-1 administration induces whole-body insulin resistance and impairs skeletal muscle insulin signaling in a rat model.
Cite This Study
Wilkes et al. (2003) studied this question.