Population
Pulmonary arteries from pulmonary hypertensive patients and control subjects, and distal human pulmonary…
Comparison
Endothelin-1 (10-10 mol/L), cicaprost… vs Control subjects and untreated cells
Design
Preclinical
Authors
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Supports ET receptor role in pulmonary vascular remodeling; leaves open clinical translation of ET antagonists.
ET(A) and ET(B) receptors are differentially distributed in human pulmonary arteries and both promote the proliferation of PASMCs in vitro, suggesting a role in vascular remodeling in pulmonary hypertension.
Davie et al. (2002) studied this question.
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