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Care for patients with kidney disease has historically organised itself around numbers: acid-base, electrolytes, clearances, albumin-creatinine ratios and eGFR trajectories. A patient phenotype such as frailty sits uncomfortably in a world of numbers: it is multidimensional, reflects cumulative damage rather than a point in time, and is subjective in its early stages(e.g., self-reported exhaustion). Yet, despite its prognostic significance, frailty in chronic kidney disease (CKD) has rarely been considered a serious therapeutic target1.
Rajesh Raj (Fri,) studied this question.