What question did this study set out to answer?

This research aims to evaluate the diagnostic value of QTc prolongation in detecting autonomic failure in individuals with diabetes.

February 1, 2000Diabetes CareOpen Access

Reassessing the role of QTc in the diagnosis of autonomic failure among patients with diabetes: a meta-analysis.

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Why the study?

Does QTc prolongation accurately diagnose autonomic failure in patients with diabetes?

Key Points

This research aims to evaluate the diagnostic value of QTc prolongation in detecting autonomic failure in individuals with diabetes.
Critically appraised 17 studies assessing QTc sensitivity and specificity for diabetic autonomic failure.
Included 4,584 patients with a mean age of 34.9 years, predominantly type 1 diabetes, with a mean duration of 14.5 years.
Summarized QTc accuracy as odds ratios and compared accuracy based on patient characteristics using receiver operating characteristic curves.
26% of patients displayed autonomic failure based on cardiovascular reflex tests.
Pooled sensitivity for QTc > 441 ms was 28% and specificity was 86%.
Autonomic failure was 2.26 times more likely in patients with QTc prolongation, with sensitivity varying by sex and age.

Structured PICO

Does QTc prolongation accurately diagnose autonomic failure in patients with diabetes?

Population

17 studies representing 4,584 patients with diabetes (mean age 34.9 years, 46% female, 92% with type 1 diabetes, mean duration of diabetes 14.5 years)

Intervention

QTc prolongation (QTc > 441+/-8 ms)

Comparator

Normal QTc

Outcome

Diabetic autonomic failure (defined as >=1.2+/-0.4 abnormal of 2.0+/-1.6 administered cardiovascular reflex tests)surrogate

QTc prolongation is a specific but insensitive indicator of diabetic autonomic failure, though its sensitivity is higher in men.

Discussion

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Implication

QTc >441 ms is specific yet insensitive for diabetic autonomic failure; confirms modest diagnostic performance and need for improved markers.

Cite This Study

Whitsel et al. (2000) studied this question.

synapsesocial.com/papers/6a19bcd87081f56b37df01ae https://doi.org/10.2337/diacare.23.2.241

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Implication

QTc >441 ms is specific yet insensitive for diabetic autonomic failure; confirms modest diagnostic performance and need for improved markers.

Reassessing the role of QTc in the diagnosis of autonomic failure among patients with diabetes: a meta-analysis.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Reassessing the role of QTc in the diagnosis of autonomic failure among patients with diabetes: a meta-analysis.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider