Key result
Diabetic autonomic neuropathy was independently associated with a significantly prolonged QTc interval compared to diabetics without neuropathy and healthy controls (408.4 vs 394.6 and 393.6 ms; P=0.001).
Why the study?
Does the severity of diabetic autonomic neuropathy affect the corrected QT interval in diabetic subjects?
Population
105 diabetic subjects (type 1, n = 53; type 2, n = 52) and 40 matched (by age and sex) control subjects.
Comparison
Presence and severity of diabetic autonomic… vs Diabetic subjects without autonomic neuropathy…
Design
Cross-sectional
Authors
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QTc prolongation may mark diabetic autonomic neuropathy severity; leaves open prospective arrhythmia risk validation.
Cross-Sectional (n=145)
Does the severity of diabetic autonomic neuropathy affect the corrected QT interval in diabetic subjects?
Absolute Event Rate: 408.4% vs 394.6%
p-value: p=0.001
The study confirms that QTc prolongation is independently associated with the severity of diabetic autonomic neuropathy.
Tentolouris et al. (1997) conducted a cross-sectional in Diabetic autonomic neuropathy (n=145). Diabetic autonomic neuropathy vs. No autonomic neuropathy and healthy controls was evaluated on Corrected QT interval (QTc) (p=0.001). Diabetic autonomic neuropathy was independently associated with a significantly prolonged QTc interval compared to diabetics without neuropathy and healthy controls (408.4 vs 394.6 and 393.6 ms; P=0.001).
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